There's certainly no love lost when it comes to Milan and Liverpool, who have major history in European competitions.
In 2005, Liverpool won arguably the most dramatic Champions League final in history in Istanbul, as they fought back from being 3-0 down at the break to earn a 3-3 draw against Milan, before subsequently winning on penalties.
The Italian giants would gain their revenge two years later in the 2007 final, however, thanks to a couple of goals from Filippo Inzaghi in a 2-1 win.
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Milan Recent Form
Milan haven't enjoyed a good start to the new season as they've managed just one win out of their opening four games, and that came at the weekend as they beat Venezia 4-0.
They've drawn two against Torino and Lazio, while they lost 2-1 against Parma.
Milan Injury News
Ismael Bennacer, Alessandro Florenzi and Marco Sportiello are all out for Milan.
There is a chance that Malick Thiaw and Davide Calabria might feature, but they are still to fully recover from a couple of niggles.
Last Milan Lineup
Here's how Milan lined up against Venezia.
Liverpool Recent Form
The honeymoon period for Arne Slot is officially over after he suffered his first defeat as Liverpool boss at the weekend in a shock 1-0 home defeat against Nottingham Forest.
Prior to that, the Reds had won three in a row against Ipswich, Brentford and Man Utd - and without conceding a single goal, too.
Liverpool Injury News
The only confirmed injury absence for Liverpool is Harvey Elliott.
Federico Chiesa was strongly linked with Milan in the summer before his late switch from Juventus to Liverpool. He is yet to make an appearance for the Reds and wasn't even in the squad on Saturday so his fitness is clearly not up to standard yet, which makes it unlikely he'll feature at San Siro.
Last Liverpool Lineup
Here's how Liverpool lined up against Forest.
Milan - Player To Watch
Milan may not have hit the ground running as a whole this season, but Christian Pulisic certainly has as he has two goals and two assists in four games to his name. He scored one and set up another against Venezia on Saturday.
Liverpool - Player To Watch
Nottingham Forest did a hell of a job keeping Mohamed Salah quiet at the weekend, as prior to Liverpool's 1-0 loss he recorded three goals and three assists in his opening three games of the season.
Milan vs Liverpool - Prediction
Before the loss against Forest, Liverpool looked extremely assured and looked to have bought into the new style set by Slot. Confidence will be hurt by the loss, but if they can shake the feeling off quickly then they should have too much for Milan, who have been less-than-inspiring in Serie A.
Scoreline prediction - Milan 1-2 Liverpool
Milan vs Liverpool - Betting Tips
Liverpool to Win and Over 2.5 Goals Scored
- Every single game Milan have played in this season has seen three or more goals scored
- Liverpool have scored two or more goals in three out of their four games
Mohamed Salah to Score
- In 16 appearances against Italian sides in the Champions League, Salah has scored nine goals and scored in his last two appearances at San Siro
